Fig 1: Levels of inflammatory cytokines in control, Fe2O3NP-exposed group, AgNP-exposed group, and Fe2O3NP and AgNP-coexposed group. (A) Levels of p53 in rat cardiac and (B) lung tissues. (C) TNF-a levels in rat cardiac and (D) lung tissues. (E) Levels of IL-6 in rat cardiac and (F) lung tissues. *P<0.05 vs. control group; #P<0.05 vs. Fe2O3NP-exposed group; $P<0.05 vs. AgNP-exposed group; &P<0.05 synergistic interactions when both NPs are combined using Factorial Design. Fe2O3NP, iron oxide nanoparticle; AgNP, silver nanoparticle; TNF-a, tumor necrosis factor- a; IL, interleukin.
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